. 6 Dispersed lesions of classical lichen planus can also occur over the Blaschko lines. They represent lines of division of the two cell lines within the embryonic skin tissue. A. As these cells divide and spread over the growing body, they form swirls and streams that create the lines of Blaschko. , 2008). One of the subjects developmental biologists are interested in is the development of pattern. To recap, since 2012 or earlier, waves of social media users searched for “humans have stripes,” “humans have invisible stripes,” or “Blaschko’s lines,” likely landing on Wikipedia’s. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. A case of erythema multiforme along Blaschko’s lines is reported in a 20-year-old female suffering from recurrent herpes labialis. Blaschko's lines are the most common pattern of mosaicism. Fungus that causes Athlete's. Citation 59 On the other hand, blaschkoid LP is differentiated from linear LP, as it adheres to Blaschko’s lines. The lines of Blaschko represent a pattern followed by many skin disorders. They do not correspond to the path of vessels / nerves / lymphatics. In conclusion, Blaschko's lines are a testament to the hidden complexities of the human body. Cases with unilateral involvement of upper and lower limbs, chest, back, and waist are even rarer. Although cases of lichen planus (LP) are not uncommon, LP with lesion distribution along the Blaschko’s lines is a rare entity, accounting for only 0. The lines of Blaschko, which are normally invisible on skin, are thought to follow the paths along which cells migrate as the skin develops before birth. This contribution provides an update on the diverse genetic etiologies. Blaschko’s lines were originally described by Dr. com Open. Alfred Blaschko是一位德国皮肤科医生，他收集了一. Blaschko’s lines are invisible developmental lines of the skin. 3. (1987) reported 2 unrelated Japanese children with early-onset reticulate hyperpigmentation distributed in a zosteriform pattern along the lines of Blaschko on the trunk and limbs, but sparing the face, palms, and soles. 1016/B978-0-444-62702-5. 2). Yeah, there were multiple things of vanilla ice cream and now they're one thing, but it's all vanilla ice cream. They never cross the anterior truncal midline but run along it. This work describes the first reported case of childhood linear DLE following the lines of Blaschko, and a review of the linear manifestations of childhood LE is presented. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. They follow a “V” shape over the back,. Incontinentia pigmenti (IP) is a rare X-linked dominant disorder, in which skin lesions distributed along Blaschko's lines appear shortly after birth. Follows Blaschko’s lines; Streaks and whorls; Fades in adolescence; The third incontinentia pigmenti stage is the hyperpigmented stage in which the skin is darkened in a swirled pattern often described as a “marble cake” appearance. Blaschko lines track distinct patterns (Figure 3). 1,2 To the best of our knowledge, there is no existing clinical approach for linear hyperpigmentation diagnosis. 1976. He was otherwise healthy with no family history of au-toimmune diseases. Blaschko's Lines. The condition was first described in 1988 by Kalter et al. Treatment with 2% topical minoxidil twice a day produced gradual elongation and thickening of the affected hairs with considerable cosmetic. He noticed that about 150 of his patients all had rashes and moles. Lupus panniculitis of the scalp (LPS) is a rare presentation of lupus erythematosus panniculitis (LEP), an inflammatory disorder of the subcutaneous fat, mostly found in 1–3% of patients with lupus erythematosus 1 LPS has the distinctive clinical feature of distribution along the lines of Blaschko, giving rise to linear, arched or annular alopecia. Mosaicism describes an individual composed of two or more genetically different. The visual appearance of X-linked skin disease can follow the pattern of lines described by the dermatologist Alfred Blaschko. The objective of this study was to consider a hypothesis of the existence of Blaschko lines in the CNS in the example of incontinentia pigmenti (IP). Pigmentary mosaicism refers to patterned hypo- and/or hyperpigmentation that results from genetic heterogeneity of skin cells. Together with new insights on the role for lysosomal signalling in embryonic stem cell differentiation, mutations in the X-linked transcription factor 3 ( TFE3. Linear LP lesions are unilateral and distributed along Blaschko lines [4], [5]. Although in the initial description 1 extracutaneous findings were not reported, HI was later recognized as a. The cause of lichen striatus is unknown. One of the subjects developmental biologists are interested in is the development of pattern. These lines are only visible in those with a mosaic The lines are believed to. In the case of somatic mutations (cutaneous mosaic ), the spread of the affected cell clone is visualized by the corresponding linear hamartoma (nevus). The nowadays well-known lines of Blaschko form streaks displaying a V-shape or fountain-like pattern on the back, an S-shape or whorled pattern over the lateral aspects of the trunk, and a linear pattern on. Keywords. Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. However, these lines can become visible if a person is suffering from a skin disease. Blaschko lines presenting as narrow bands are common in mosaic disorders (e. The most common clinical patterns are streaks and swirls following Blaschko's lines in narrow or broad bands and a block-like distribution. ream@nationwidechildrens. The. 本专题将讨论线状苔藓的发病机制. thought to represent pathways of epidermal cell migration and proliferation during the development of the fetus; become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns Blaschko’s lines (BL) are considered systematized cutaneous developmental patterns during embryogenesis that are different from vascular, neural, or lymphatic pathways. The main purpose of this article is to introduce the concept of Blaschko's lines into the medical, paramedical, and general biological fields of science, and it is hoped that some inter‐reaction can occur between those who regularly see and study other chromosomal and embryological abnormalities. Both HI and LWNH encompass heterogeneous groups of disorders characterized by conditions with hypopigmented or hyperpigmented skin. Congenital lesions may include incontinentia pigmenti and variants of epidermal nevi. Unlike. Pigmentary mosaicism refers to patterned hypo- and/or hyperpigmentation that results from genetic heterogeneity of skin cells. Human skin is overlaid with what dermatologists call Blaschko’s Lines, a pattern of stripes covering the body from head to. Lines similar to ‘Blaschko's lines’ have also been described in eyes and teeth. It depends on their location. 1 and 5. Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. Blaschko’s lines. Blaschko's lines also hold a deeper philosophical significance. We investigated a female Labrador Retriever and her crossbred daughter, which both showed similar clinical lesions that followed Blaschko's lines. The lines trace how one cell in a baby divided and grew. Different descriptive terms for these disorders include "linear and whorled nevoid hypermelanosis" (LWNH), [1] "progressive cribriform and zosteriform. On the chest and upper back they rise in a swirl before. 219. Males and females with certain skin conditions and other conditions will also show it under visible light or UV light. Cases of LP involving multiple segments of the body along the Blaschko’s lines with nail damage are rare, and the diagnosis was established based on dermoscopy and skin biopsy. The lines of Blaschko are a pattern of lines on the skin that represent the developmental growth pattern during epidermal cell migration. The proband (III-4) is an eight-year-old Yakut. These diseases are hypothesized to be caused by genetic mosaicism resulting from processes such as lyonization or somatic postzygotic mutation. 布拉什可氏線（英語： Blaschko's lines ），為根據皮膚的胚胎生長方向畫出之假想線 ，正常的人體無法看到布拉什可氏線，但某些皮膚和黏膜疾病會沿此線生長，而導致背部出現V字型的條狀病灶，胸部及側面出現S字形的條狀病灶，頭部則出現波浪狀病灶 。 布拉什可氏線是基因的鑲嵌現象 ，不會出現. 7 The majority of LPP. Follows lines and swirls called Blaschko lines ; Usually unilateral, but may be bilateral and widespread in severe cases. This section has been translated automatically. Lichen striatus (LS) is uncommon and occurs most frequently in children. Background: Lichen planus (LP) with distribution of lesions along Blaschko's lines is a rare entity, accounting for 0. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal nerves. Lichen sclerosus along Blaschko's lines on left chest. The initial appearance was reddish hyperkeratotic. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. Typically these lines are not visible; however. TLDR. ”. 发音 blaschko's lines 2 音频发音, 更为 blaschko's lines. [7,8] Modified Blaschko's lines proposed by Happle and Assim is currently the most widely accepted one for head and neck area. The BL were described and drawn by Alfred Blaschko, a German dermatologist, in 1858-1922 [ 1, 2 ]. The Blaschko’s lines result from the fact that some of a chimera's skin cells say “make darker skin” and some say “make lighter skin. Unconcerned; nonchalant: had a blasé attitude about housecleaning. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. The lines of Blaschko represent a pattern followed by many skin disorders. The term "pigmentary mosaicism" refers to patterned hypo- or hyperpigmentation resulting from a clone of skin cells with altered ability to produce melanin [ 1 ]. A diagram of the distribution pattern of these lines has since been drawn and is now referred to as the lines of Blaschko. A. Diagnosis is made based on clinical appearance of 2 to 4 mm, flat-topped, lichenoid papules ranging from red color to flesh color that are distributed linearly and may be discrete or. Blaschko's lines. Four other patterns of mosaicism are also di. They do not follow neural, vascular, or lymphatic structures and are distinct from dermatomes as well as Langer′s lines. 1. Out of the 3 reported cases of linear LSA that appeared on the face, one case showed facial lesion following the Blaschko's line without any oral mucosal lesion, and the other 2 cases showed additional oral mucosal. Multiple Craniofacial Nodules and Plaques Distributed Bilaterally Along Blaschko Lines. Can be smooth or verruciform. They are named after German dermatologist Alfred Blaschko, who first described them in 1901. [2,3] In contrast to dermatomes, Blaschko's lines form a V-shape over the spine and an S-shape on the lateral and anterior aspects of the trunk. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large patches. The main differential diagnoses are the other linear dermatoses that run along Blaschko's lines, especially an inflammatory linear verrucous epidermal naevus (ILVEN), however, when compared to lichen striatus, ILVEN have the following characteristics: 75% of lesions arise during the first five years of life, most often in the first six months Blaschko lines are distinctive whorled and linear patterns on the skin first described by the dermatologist Alfred Blaschko in 1901. These lines are invisible under normal conditions. [French, from past participle of blaser, to cloy, from French dialectal, to be chronically hung over, probably from Middle Dutch blāsen, to blow up, swell; see bhlē- in. (1989) provided a diagram of Blaschko lines, which were first described by Blaschko (1901). These were first demonstrated by German dermatologist Alfred Blaschko in 1901. Linear psoriasis is an unusual clinical variation of psoriasis that manifests segmentally along the lines of Blaschko. 1,2 There are several terms for this entity, including linear LP, Blaschkolinear LP, and Blaschkoid LP. In our case, the cytogenetic analysis on. On comparing the overlays of all body and head lesions with the original lines of Blaschko there was an excellent correlation. Start your 7-day free trial to. The lines of Blaschko represent developmental pathways of ectoderm, and several skin diseases may show Blaschko-linear manifestations, often arising as a result of postzygotic mutations. 5-1 cm hypopigmented or white macules that merge to form larger patches; Macules cover more than two dermatomes and are often on both sides of the body; Patches are not symmetricalFor example, Blaschko's lines were present in a girl with a karyotype mos 47,XX,+7/45,X (Niessen et al. 1 Mendelian diseases may present in this manner at birth but complex traits may also manifest like this later in life. I've made some changes to the article and added inline citations throughout. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. Pigmentary mosaicism refers to patterned hypo- and/or hyperpigmentation that results from genetic heterogeneity of skin cells. The most common presenting symptoms of classical LS may include dryness and pruritis ranging to mild to severe. These lines are only visible in those with a mosaic The lines are believed to trace the migration of embryonic cells. These lines follow a predictable pattern and usually appear in a V or S shape. The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. Iijima et al. These lines may express different amounts of melanin, or become visible due. Jackson: The lines of Blaschko: a review and reconsideration: Observations of the cause of certain unusual linear conditions of the skin. Blaschko’s lines are embryonal, epidermal cell lines distinct from the dermatome, and cutaneous lesions following Blaschko’s lines are a manifestation of cutaneous mosaicism [5]. For easier comparison, a simplified form of the latter that had fewer. The lines of Blaschko represent a pattern followed by many skin disorders. The lines of Blaschko were first described in 1901 and represent a pattern that is observed in many skin disorders. Type 1b Blaschko lines are so broad that it is sometimes difficult to even identify a linear pattern. The shape of Blaschko represent a pattern assumed on many different nevoid and acquired skin diseases on the humanitarian skin and mucosae. The lines were discovered by German dermatologist Alfred Blaschko 75 years ago, Dr Bav Shergill, of the British Association of Dermatologists told MailOnline. They are called *Blaschko's lines* and form along the paths of embryonic cell migration. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow. Oral antibiotic therapy is the mainstay of treatment. The stripes on humans are called Blaschko’s lines,. She showed small-sized or aplastic fingernails on the right hand. They become. Typically these lines are not visible; however. Linear and whorled nevoid hypermelanosis (LWNH) is a pigmentation disorder characterized by macular hyperpigmentation following the lines of Blaschko. The distribution of skin conditions along Blaschko’s lines that involve dermal processes is thought to be due to epidermal mutations that lead to changes in dermal tissues. 1 Linear cutaneous lesions are those that occur along imaginary skin lines like Blaschko’s lines, lymphatics, and blood vessels or those with. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. Swirling patterns around the trunk and linear patterns down the legs and arms are referred to as Blaschko's lines; Lesions first appear as small 0. The present CME article will highlight important. Nails of the left hand were also affected (Fig. According to this result, the linear hypomelanotic lesions along Blaschko's lines in HI may develop as a consequence of mosaicism of epidermal cells. Blaschko's lines, also called the Lines of Blaschko, are skin lines invisible under normal conditions. This contribution provides an update on the diverse genetic etiologies. When six-months-old, there were Blaschko linear,. Lichen striatus is clinically diagnosed on the basis of its appearance and characteristic developmental pattern following the lines of Blaschko. Uranium glass or vaseline glass. Blaschko lines correspond with cell migration or growth pathways that are established during embryogenesis. LPP along Blaschko's lines has been associated with susceptibility to genetic mosaicisms. A 14-year-old girl, born of a third-degree consanguinous marriage, came to us recently, with multiple grouped pits filled with black plugs over left cheek, left side of. 2. Net Letter Nevus comedonicus along Blaschko’s lines Sir, groups of dilated follicular openings filled with black, Nevus comedonicus is an uncommon skin abnormality hard plugs, distributed over left cheek, left arm and first described in 1895 by Kofmann who used the term forearm, left side of the chest [Figure 1], abdomen, left “comedo-nevus”. RHOA-related neuroectodermal syndrome is characterised by linear skin hypopigmentation along Blaschko's lines associated with alopecia, leukoencephalopathy, facial and limb hypoplasia, and ocular, dental, and acral anomalies. Lichen striatus (LS) is an uncommon linear dermatosis that most commonly affects children aged 4 months to 15 years and is distributed along the lines of Blaschko. Blaschko’s lines are named after Alfred Blaschko, a German dermatologist who first described them in 1901. 5 months. Certain unusual variants of LP may present a difficulty in diagnosis. Objective: The aim of the study was to elaborate this pattern in a comprehensive way. Close. (A) Blaschko lines distributed lesions (2-weeks-old). Blaschko′s Lines. A diagram of the distribution pattern of these lines has since been drawn and is now referred to as the lines of Blaschko. 5 These lines are curved over scalp. Dear Editor, Lichen striatus (LS) is a self-limiting linear dermatosis that predominantly affects children aged 5 months to 15 years and is distributed along the lines of Blaschko. Lichen striatus is a rare, benign, self-limited linear dermatosis of unknown origin that predominantly affects children. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. On the basis of studies of linear skin diseases, Jackson (1976) reviewed Blaschko's work and reproduced some of the original drawings. They never cross the previous truncal middle line But run for it. Department of Dermatology, Yale University School of Medicine, New Haven, CT. Through x chromosome inactivation, lineage of epithelia cells can be seen to be distributed in lines horizontal to the body A–P axis. 24%-0. Finally, we differentiate Blaschko's. We report a case of an eight-year-old boy with mucopolysaccharidosis (MPS) II with atypical skin lesions of hyperpigmented streaks along Blaschko’s lines. This is a review of case reports providing photographically documented evidence that the lines of Blaschko become manifest in. Blaschko's lines are invisible on the majority of humans, including under UV. Acquired blaschkoid dermatitis is unilateral — it only affects one side of the body. thought to represent pathways of epidermal cell migration and proliferation during the development of the fetus; become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. Like dermatomes, they are linear on the limbs and circumferential on the. Ophthalmologic evaluation revealed right microphthalmia, aniridia and sclerocornea. 24%-0. They run down the arms and legs. They were described and drawn by Blaschko 75 years ago. Somatosensation includes feedback from mechanoreceptors, thermoreceptors, proprioceptors, pain receptors, and chemoreceptors. To our knowledge, the dermatoscopic features of pigmented lesions in LWNH have not been described previously. Cutaneous mosaicism does not always follow Blaschko lines, which may relate to the time the mosaicism arises during embryonic development. Very few cases of bilateral. In this paper, we presented a 47. The lesions following Blaschko's lines in PCZH may reflect the clonal migration and proliferation of embryonic melanoblasts, resulting in peculiar cutaneous patterns. A case of male patient with adult blaschkitis presenting as unilateral asymptomatic erythematous edematous papules, papulovesicles, and plaques over Blaschko's lines, in which skin biopsy revealed coexistent pathological features of lichen striatus and adult blaschkitis along with blood eosinophilia, has been presented here. Citation 59 On the other hand, blaschkoid LP is differentiated from linear LP, as it adheres to Blaschko’s lines. Blaschko's lines, also called the Lines of Blaschko, are skin lines invisible under normal conditions. INTRODUCTION. Beilage zu den Verhandlungen der Deutschen Dermatologischen Gesellschaft VII Congress, Breslau, 1901. Treatment is difficult and consists of avoidance of triggers and topical and systemic medications in order to. in 1998 to reflect the linear nature of the diseaseTo date, there have been 16 documented cases of linear alopecia diagnosed as chronic cutaneous lupus erythematosus occurring in a linear configuration following Blaschko's lines. On the trunk and limbs the linear arrangement is usually easily distinguishable, but recognizing that a small lesion on the face follows Blaschko lines can be difficult in some patients (eg, the epidermal nevus represented in Fig 1, A. facebook; twitter; reddit; linkedin; email; print; By pharyngula on August 12, 2010. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. Citation 58 Linear or zosteriform LP is an uncommon variant that follows the Koebner phenomenon, does not adhere to Blaschko’s lines, and rarely follows a dermatomal arrangement. Lichen striatus is a self-limited lichenoid eruption that follows Blaschko’s lines. These lines are invisible under normal conditions. Pigmentary mosaicism refers to patterned hypo- and/or hyperpigmentation that results from genetic heterogeneity of skin cells. . This mysterious. Approximately 10% of patients with LP. [] proposed the term ‘linear cutaneous lupus erythematosus (LCLE)’ for DLE with a linear configuration. Objective: The aim of the study was to elaborate this pattern in a comprehensive way. Blaschko’s Lines. Blaschko lines correspond to the path of embryonic cells as they grow outward from the dorsal midline toward the ventral. In McCune-Albright syndrome, the segmental hyperpigmentation runs in such broad bands that it is often difficult to appreciate the link to Blaschko’s lines. Conditions of the human integumentary system. Lines of Blaschko are usually invisible unless genetic mutations result in mosaicism that alters the pigmentation, proliferation, and/or differentiation of epidermal cells. Although they are most recognized in people with. These lines were painstakingly and thoroughly documented first by German dermatologist Alfred Blaschko. They curve around the sides, like tiger stripes. A healthy 7-year-old girl presented to our clinic with bilateral asymmetric LS occurring on the right arm and left leg of 1-year duration. The archetypal figure has been subsequently updated by others and is represented elsewhere with greater detail in regions such as the head and neck (see Happle and Assim, 2001). LAM coinciding with localized linear scleroderma was diagnosed and is described as hyperpigmentation of the basal layer without the involvement of the dermis and subcutaneous tissue. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. Cutaneous conditions can follow Blaschko's lines on the skin, which are thought to reflect patterns of cell migration and clonal expansion during embryonic development of the epidermis. 2. B, Equivalent. The British. 62% of all patients. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large patches without midline separation and lateralization. 线状苔藓是获得性、炎症性皮肤病，呈自限性，皮损线状排列，无其他症状，主要发生于儿童，一般单侧发疹，最常累及四肢，沿Blaschko线连续性或间断性分布。起病突然，数周内全面进展，通常在6-12个月内消退。本专题将讨论线状苔藓的发病机制、临床表现、诊断和治疗。Cutaneous conditions can follow Blaschko's lines on the skin, which are thought to reflect patterns of cell migration and clonal expansion during embryonic development of the epidermis. It is also important to mention that not all XX/XY individuals are chimeras. Lichen striatus is a rare, benign, self-limited linear dermatosis of unknown origin that predominantly affects children. Method: One hundred eighty-six figures showing skin lesions following Blaschko's lines on the head and neck were collected from literature. They run down the arms and legs and curve around the sides like tiger stripes. 1. Keratinocytic epidermal nevi are also known as linear epidermal nevi or verrucous epidermal nevi, based on characteristics of their appearance. Blaschko’s lines, also called the Lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. Introduction. Literature. When there is a big difference between the two. However, cats lack the visual capabilities to perceive these lines as they primarily rely on their excellent night vision and motion detection abilities rather than perceiving intricate patterns on the skin. Blaschko’s lines are named after Alfred Blaschko, a German dermatologist who first described them in 1901. Lines of Blaschko doi: 10. Epidermal FIGURE 1 Clinical features and histopathological findings. Fig 2 Acne on the back at age 17 years, with more severe involvement in a blaschkoid distribution on the left. Blaschko’s lines are actually traces of the migration and proliferation of skin cells during embryonic development. Neither a specific disease nor a predictable symptom of a disease, Blaschko's lines are an invisible pattern built into human DNA [citation. Blaschko’s lines are a fascinating part of our genetic code and a reminder of the complexity and diversity of the human body. Over the course of years of examining thousands of patients, he often observed people who exhibited unusual patterns of dark stripes and swirls that encompassed their entire bodies. 起病突然，数周内全面进展，通常在6-12个月内消退。. Preliminary results support the ideas that (1) Blaschko's lines represent single clones of epidermal cells; (2) in patients with HI and severe neurological involvement mosaicism, if detectable, is best shown in keratinocytes; and (3) the cytogenetic defect in epidermis may be directly responsible for the failure of pigmentation in HI. Show Stuff You Should Know, Ep Short Stuff: Blaschko's Lines - Oct 12, 2022The line was actually, "Blaschko's lines are an invisible pattern built into human DNA. Most of these cases combined features of LP pigmentosus, LP pilaris, and atrophic LP. We report two cases of localized, unilateral, linear LP hypertrophicus along the lines of Blaschko. The macules spread across her body and increased in number following Blaschko’s lines (Fig. identified a similar case and coined the term “linear atrophoderma of Moulin” []. Mosaicism describes an individual composed of two or more genetically. Lichen striatus is clinically diagnosed on the basis of its appearance and characteristic developmental pattern following the. It was previously known as zebra-like hyperpigmentation, zosteriform lentiginous nevus, and zosteriform hyperpigmentation. 5. The most common clinical patterns are streaks and swirls following Blaschko's lines in narrow or broad bands and a block-like distribution. What are Blaschko Lines and what do they look like? Blaschko lines are markings that can be found on the skin of some people. Hypopigmented lesions following the lines of Blaschko are usually the presenting feature. According to the affected skin com-ponents, epidermal nevi have been divided into organoid (with abnormal adnexal components, such as the hair follicles, seba-Seventeen cases of childhood discoid lupus erythematosus (DLE) have been previously reported in the literature. Skin findings of KD are polymorphous, varying from diffuse maculopapular eruptions to psoriasiform lesions. These lines are invisible under normal conditions. The causes for occurrence in a linear pattern include lesions following Blaschko's lines, blood vessels, lymphatics and dermatomes; due to Koebner’s phenomenon and auto inoculation; external factors; infestations like cutaneous larva migrans and burrows of scabies. Acquired Blaschkoid lesions include rare reports of psoriasis, atopic dermatitis, lupus erythematosus, fixed drug eruption, graft-versus-host disease, and erythema multiforme. The patient was diagnosed with SV along Blaschko's lines (Fig. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. Danarti et al 4 postulated that LAM may reflect the action of an autosomal lethal gene surviving by mosaicism. It is characterised by skin abnormalities in the form of unilateral or bilateral cutaneous macular hypopigmented whorls, streaks and patches, corresponding to Blaschko’s lines. These lines are. The system of Blaschko's lines on the head and neck as elaborated by this study is more precise than previously published diagrams and shows definite crossing of lines. , BMC Medical Genetics , 2011 ) Mutations involving color-producing cells can lead to pigmentary mosaicism presenting as streaks and swirls following Blaschko lines. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. [1][2][3] The lines can be observed in other animals such as cats and dogs. In heterozygous females affected by an X-linked skin disorder, lesions often appear in a characteristic pattern, the so-called Blaschko's lines. These lines are only visible in those with a mosaic skin condition or in chimeras where different cell lines contain different genes. The concept of Blaschko’s lines were first introduced by Alfred Blaschko in 1901. They only become apparent if a person’s cells make two different colors of skin. French dermatologists Gourgerot and Carteaud first described confluent and reticulated papillomatosis in 1927 [1]. Human skin is covered in stripes. Acquired blaschkoid dermatitis is unilateral — it only affects one side of the body. In 1998, when reporting 2 cases of linear childhood CLE following the lines of Blaschko, Abe et al. Blaschko’s lines are named after Alfred Blaschko, a German dermatologist who first described them in 1901. 2021. It is caused by an altered clone of melanocytes (pigment cells) with a decreased ability to make melanin (brown pigment). Blaschko. Verrucous lesions were present at the same time with scarce vesicles. g. An epidermal naevus usually arises on the trunk and limbs and is uncommon on the face or scalp. Alfred Blaschko in 1901 when he examined over 140 patients with linear skin lesions that followed similar patterns. These lines are only visible in those with a mosaic The lines are believed to trace the migration of embryonic cells. This case presented with mild symptoms of MPS such as hepatosplenomegaly, joint stiffness, and quite mild bone deformity, which was the reason for the delay in diagnosis until the age. Lichen striatus is a rare, benign, self-limited linear dermatosis of unknown origin that predominantly affects children. SUMMARY. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. Fig 1 Acne predominantly on the left upper portion of the back at age 15 years. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal nerves. (a) Blaschko's lines. The LCLE is a highly unusual variation of discoid lupus erythematosus (DLE) []. 1016/s0190-9622 (94)70143-1. Very sophisticated. The peripheral rim can be translucent or slightly pigmented and centre can have dotted vessels or blue/gray dots/granules based on the. , 1984), not having the complexity of the lines and whorls, but are rather a series of broad linear bands which show a midline dip. 1, 2 To the best of our knowledge, there is no existing clinical approach for linear hyperpigmentation diagnosis. Cutaneous mosaicism does not always follow Blaschko lines, which may relate to the time the mosaicism arises during embryonic development. LWNH refers to the swirls and whorls of hyperpigmentation distributed along Blaschko’s lines. Disease with presentation along Blaschko’s lines Dermoscopic features; Porokeratosis: Well-defined peripheral white-coloured rim with two free edges continuous or broken at some parts (“white track”). OBJECTIVE The aim of the study was to elaborate this pattern in. Alfred Blaschko is credited with the first demonstration of these lines in 1901. It is particularly common in children and rarely seen in adults. Blaschko's lines represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. Blaschko's lines are consistently V-shaped at the top of the spine, S-shaped across the abdomen, inverted U-shaped from the breast area to the upper arm, and perpendicular down the front and back of the lower extremities. Lichen planus (LP) is an idiopathic inflammatory skin condition affecting the skin and mucosa. Here, we report a case of this rare disorder and have put forward an argument why. Like dermatomes, they are linear on the limbs and circumferential on the trunk. 2) 3. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal. Alfred Blaschko in 1901 when he examined over 140 patients with linear skin lesions that followed similar patterns. Blaschko’s lines was reported by Richarz et al. Blaschko's lines also termed as the lines of Blaschko, are believed to represent normal cell development in the skin. Blaschko Lines in Broad Bands. They are thought to represent the pathways of epithelial migration and proliferation in the foetus. 62% of all patients. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. We present this case and a brief review of the most commonly acquired linear eruptions following Blaschko's lines with the goal of expanding the histopathologic findings that may be encountered in adult blaschkitis. were the first to describe a seemingly unidentified entity characterized by the presence of hyperpigmented and atrophic band-like lesions that closely followed Blaschko’s lines []. They were described and drawn by Blaschko 75 years ago. The lines of Blaschko were first described in 1901 by the German dermatologist Alfred Blaschko, who published a book comprising hand drawings of linear lesions of the skin from various parts of the body and a unique collection of 175 patients with epidermal naevi, sebaceous naevi, or naevus angiolipomatosus, as well as acquired. The lines of Blaschko form a "V" shape over the spine, "S" shapes over the lateral and anterior aspects of the trunk, and a linear pattern over the extremities. Blaschkitis is an uncommon inflammatory dermatosis of unknown etiology, usually affecting adults. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal. Lichen striatus is an acquired inflammatory dermatosis that follows the lines of Blaschko. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large patches. Blaschko’s lines are attributed to the migration lines of epidermal cells during embryogenesis and are characterized by a V-shaped pattern on the posterior midline, S-shape on the abdomen, and spiral on the posterior scalp. Unilateral distribution of lesions in arm, leg, trunk, and waist is even less common. They run down the arms and legs. Over 50% of cases occur in children aged between 5 and 15 years. Finally, there is a rare atrophic variant of LP [1], [2]. 11 The lines are visible and present in S-shaped, V-shaped, or even U-shaped patterns. Pigmentary nevi represent nevi with altered pigmentation. Inherited factors in the affected skin, rather. A 24‐year‐old woman with a 3 year history of Blasehkitis is presented with a dermatosis consisted of erythematous vesicular papules following BlaseHko's lines on her left trunk, which demonstrated a perivascular inflammatory infiltrate in the subpapillary dermis with lymphocytic exocytosis. Blaschko’s lines.